The combination of Chlorhexidine Digluconate (CHX), professional reference for plaque control and Cetylpyridinium Chloride (CPC), included in GUM Paroex products, has the long-lasting ability to attack the structure of existing plaque and prevent the growth of bacteria and toxins responsible for its formation.
The superior efficacy of GUM Paroex in the plaque control was proven by an independent study* with the following results:
- GUM PAROEX 12% CHX + 0.05% CPC is clinically proven to have a more pronounced effect in reducing plaque (vs. CHX/ADS) and gum problems than other usual mouthrinses containing CHX (Fig. 1, Fig. 2).
- The clinical efficacy of GUM PAROEX 12% CHX + 0.05% CPC is significantly superior to 0.12% CHX/ALC in controlling gum problems (Fig. 1).
- 20% CHX/ADS efficacy is comparable to a 0.05% Sodium Fluoride mouthrinse, without any active antibacterial agent (Placebo) (Fig. 1).
- GUM PAROEX 12% CHX + 0.05% CPC clinical efficacy in helping control gum problems is significantly superior to 0.20% CHX/ADS (Fig. 1).
- The taste of GUM PAROEX 0.12% CHX + 0.05% CPC is well-accepted and significantly better than 0.12% CHX/ALC and 0.20% CHX/ADS formulation. This promotes better patient compliance to treatment (Fig. 3).
- The staining of GUM PAROEX 0.12% CHX + 0.05% CPC is equivalent to the staining produced by 0.12% CHX/ALC or 0.20% CHX/ADS based on subjective patient evaluation (Fig 4).
Fig.1. Mean Gingival index (GL) change Day 0 - Day 21 in 17 patients. Different letters indicate statistically significant differences in the mean GL change Day 0 - Day 21 between treatment groups.
Fig.2. Mean QHI (plaque level) change Day 0 - Day 21 in 17 patients. Different letters indicate statistically significant differences in the mean QHI change Day 0 - Day 21 between treatment groups.
Taste acceptance (0- Non acceptance; 8 - High acceptance Fig. 3. Subjective taste of the different mouth rinses evaluated by the VAS method at Day 21 on 17 patients. Different letters indicate statistically significant differences between treatment groups at Day 21.
Staining evaluation (0- No stains ; 8 - Strong stains) Fig. 4. Subjective tooth staining of the different mouth rinses evaluated bz 17 patients at Day 21. Different letters indicate statistically significant differences between treatment groups at Day 21.
References
* Per Ramberg et al. Effect of Chlorhexidine/Cetylpyridinium Chloride on plaque and gingivitis: abstract ID# 182859 IADR WCPD Budapest 2013
Gingival Index (GI) - measure of periodontal disease based on the severity and location of the lesion.
Plaque Index (QHI) - an index for estimating the status of oral hygiene by measuring dental plaque that occurs in the areas adjacent to the gingival margin.
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